Minimally-invasive Image-guided Biopsy

Investigator: Brooks Lindsey

Approximately one third of pancreatic tumors are misdiagnosed, delaying diagnosis by an average of 3 months, during which tumor size may increase by 40-50%.  Effective imaging via functional endoscopic ultrasound imaging may allow us to 1) guide biopsy in order to correctly diagnose earlier-stage tumors, and 2) determine in which patients a true “R0” surgical resection (i.e. “clean” margins) is possible.

(A) A custom mechanically-steered, contrast-specific endoscopic ultrasound transducer operating at 20 MHz (1.1 mm diameter) was developed and used to acquire (B) conventional (grayscale lumen) and contrast agent-specific imaging volumes (red microvessel)