CT Guided Percutaneous Cryovagotomy for the Management of Moderate Obesity

J. David Prologo, MD, FSIR, ABOM-D. Co-Investigators – Emory Interventional Radiology

Currently 1/3 of the world and 2/3 of the US population are overweight. Historical strategies for weight loss have consistently resulted in failure rates up to 95%. Recent research in the fields of obesity medicine and bariatrics have elucidated complex survival based mechanisms responsible for hunger and difficulty managing calorie restriction. Part of this system exists as a hunger hormone neural signaling pathway between the stomach and the brain mediated by the vagus nerve. Surgical transection of the vagus nerve has shown to decrease hunger and lead to weight loss. This trial is enrolling patients to undergo a percutaneous “freezing” of the vagus nerve under CT guidance for the potential management of obesity.

Figure. Reconstructed CT image from a cryovagotomy. The cryoablation probe (blue arrow) is placed through the skin under CT guidance to the posterior vagal trunk (yellow line), just posterior to the esophagus (black arrow).